Target-focused compound libraries
Target-focused compound libraries are designed to interact with an individual protein target or target-families. Target-focused libraries are used for assay validation followed by assay development; rapid hit generation when initiating new drug discovery projects; or hit validation generated around the newly identified active compounds in a screening campaign.
Assay development and screening services
Assay development and screening services support our partners’ projects in the early phase of drug discovery (SLIDE1). We are able to offer fragment based (SLIDE2), biochemical assays (SLIDE3-8) and cellular assays (SLIDE9) covering most of the major target classes. Assay development and screening is supported by our in-house recombinant protein production and cell culture facilities.
MT and HT assays are conducted in 96-well and 384-well plate formats. Plate handling is fully robotized using proper liquid handling devices and integrated readers. Assay read-outs include fluorescence, luminescence, absorbance and radioactivity. Beside TargetEx’ available assays the clients’ assays can be accommodated to our facilities.
‘Beside TargetEx’ available assays the clients’ assays can be accommodated to our facilities. ’
Quality of screening is continuously monitored by well-established statistical parameters (z’-factor, S/B ratio) and reported to the client as part of the study report delivered periodically or at the end of the campaign.